Lactato ringer comparado con solución salina normal en la aparición de desenlaces clínicos adversos en pacientes con shock séptico atendidos en el Hospital Belén de Trujillo
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Date
2024-07-16
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Universidad Nacional de Trujillo
Abstract
El shock séptico es una condición médica grave que conlleva una alta morbimortalidad y demanda una significativa cantidad de recursos en el sistema sanitario. La fluidoterapia es crucial en el tratamiento inicial de estos pacientes, y recientes estudios sugieren que las soluciones balanceadas como el Lactato de Ringer podrían ofrecer ventajas sobre la solución salina normal. Objetivo: Comparar Lactato de Ringer con solución salina normal en la aparición de desenlaces clínicos adversos en pacientes con shock séptico. Materiales y Métodos: Estudio prospectivo, comparativo y de cohortes realizado entre enero y junio de 2024 en el Hospital Belén de Trujillo. La muestra incluye pacientes mayores de 18 años con diagnóstico de shock séptico, excluyendo aquellos con enfermedades cardiacas, hepáticas, renales crónicas, VIH, u otros tipos de shock. Se seleccionarán aleatoriamente 375 pacientes (209 recibirán Lactato de Ringer y 166 solución salina normal), luego se registrarán desenlaces clínicos adversos, como injuria renal aguda, hipercloremia y mortalidad intrahospitalaria. Los datos serán analizados mediante tablas de distribución de frecuencias y pruebas estadísticas, incluyendo la prueba Chi-cuadrado. Resultados: Se determinará la frecuencia de desenlaces clínicos adversos en ambos grupos. Se compararán las tasas de injuria renal aguda, hipercloremia y mortalidad entre los pacientes que recibieron Lactato de Ringer y los que recibieron solución salina normal. Conclusiones: El estudio evaluará si Lactato de Ringer está asociado con una menor incidencia de desenlaces clínicos adversos en comparación con solución salina normal.
Abstract Septic shock is a serious medical condition that entails high morbidity and mortality and demands a significant amount of resources in the health system. Fluid therapy is crucial in the initial treatment of these patients, and recent studies suggest that balanced solutions such as Lactated Ringer's may offer advantages over normal saline. Objective: Compare Lactated Ringer's with normal saline in the occurrence of adverse clinical outcomes in patients with septic shock. Materials and Methods: Prospective, comparative and cohort study carried out between January and June 2024 at the Belén Hospital in Trujillo. The sample includes patients over 18 years of age with a diagnosis of septic shock, excluding those with heart, liver, chronic kidney disease, HIV, or other types of shock. 375 patients will be randomly selected (209 will receive Ringer's Lactate and 166 will receive normal saline), then adverse clinical outcomes will be recorded, such as acute kidney injury, hyperchloremia, and in-hospital mortality. The data will be analyzed using frequency distribution tables and statistical tests, including the Chi-square test. Results: The frequency of adverse clinical outcomes in both groups will be determined. Rates of acute kidney injury, hyperchloremia, and mortality will be compared between patients receiving Lactated Ringer's and those receiving normal saline. Conclusions: The study will evaluate whether Lactated Ringer's is associated with a lower incidence of adverse clinical outcomes compared to normal saline.
Abstract Septic shock is a serious medical condition that entails high morbidity and mortality and demands a significant amount of resources in the health system. Fluid therapy is crucial in the initial treatment of these patients, and recent studies suggest that balanced solutions such as Lactated Ringer's may offer advantages over normal saline. Objective: Compare Lactated Ringer's with normal saline in the occurrence of adverse clinical outcomes in patients with septic shock. Materials and Methods: Prospective, comparative and cohort study carried out between January and June 2024 at the Belén Hospital in Trujillo. The sample includes patients over 18 years of age with a diagnosis of septic shock, excluding those with heart, liver, chronic kidney disease, HIV, or other types of shock. 375 patients will be randomly selected (209 will receive Ringer's Lactate and 166 will receive normal saline), then adverse clinical outcomes will be recorded, such as acute kidney injury, hyperchloremia, and in-hospital mortality. The data will be analyzed using frequency distribution tables and statistical tests, including the Chi-square test. Results: The frequency of adverse clinical outcomes in both groups will be determined. Rates of acute kidney injury, hyperchloremia, and mortality will be compared between patients receiving Lactated Ringer's and those receiving normal saline. Conclusions: The study will evaluate whether Lactated Ringer's is associated with a lower incidence of adverse clinical outcomes compared to normal saline.
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Keywords
Shock Séptico, Fluidoterapia, Lactato Ringer, Solución Salina, Mortalidad