Efecto del extracto etanólico de Solanum tuberosum L. “huayro” sobre úlcera gástrica inducida en Mus musculus BALB/c
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Date
2024
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Universidad Nacional de Trujillo
Abstract
El objetivo de la investigación fue determinar el efecto del extracto etanólico de Solanum tuberosum L. “huayro” sobre úlcera gástrica inducida en Mus musculus BALB/c. Se obtuvo el extracto de la cáscara del tubérculo de Solanum tuberosum ecotipo “huayro” con etanol ácido (HCl) al 96% a pH 3; se trabajó con siete grupos de cinco ratones hembra cada uno a los que se indujo úlcera gástrica con 50 mg de indometacina/Kg peso corporal (p.c.) vía oral (v.o.), a excepción del grupo control negativo; los grupos fueron: Grupo Control Negativo (GCNG): sin úlcera y con 0,5 mL de solución salina fisiológica (SSF) v.o., Grupo Control Positivo (GCPS): con úlcera y con 0,5 mL de SSF v.o., Grupo Estándar Ranitidina (GERN): con úlcera y tratado con 50 mg/Kg p.c. de ranitidina v.o., Grupo Estándar Omeprazol (GEOM): con úlcera y tratado con 50 mg/Kg p.c. de omeprazol v.o., Grupo Huayro 100 (GH100): con úlcera y tratado con 100 mg/Kg p.c. de extracto de S. tuberosum v.o., Grupo Huayro 200 (GH200): con úlcera y tratado con 200 mg/Kg p.c. de extracto de S. tuberosum v.o., Grupo Huayro 400 (GH400): con úlcera y tratado con 400 mg/Kg p.c. de extracto de S. tuberosum v.o.. Se determinó que el extracto etanólico de Solanum tuberosum L. “huayro” posee efecto gastroprotector sobre úlcera gástrica inducida en Mus musculus BALB/c.
The objective of the research was to determine the effect of ethanolic extract of Solanum tuberosum L. "huayro" on induced gastric ulcer in Mus musculus BALB/c. The ethanolic extract of Solanum tuberosum ecotype "huayro" tuber peel was obtained with 96% acid ethanol (HCl) at pH 3; seven groups of five female mice each were induced with gastric ulceration with 50 mg indomethacin/kg body weight (b.w.) orally (v.o.), with the exception of the negative control group; the groups were: Negative Control Group (GCNG): no ulcer and 0.5 mL physiological saline solution (PSS) v.o., Positive Control Group (GCPS): with ulcer and with 0.5 mL SSF v.o., Standard Ranitidine Group (GERN): with ulcer and treated with 50 mg/kg b.w. ranitidine v.o., Standard omeprazole group (GEOM): with ulcer and treated with 50 mg/kg b.w. omeprazole v.o., Huayro group 100 (GH100): with ulcer and treated with 100 mg/kg b.w. S. tuberosum extract v.o., Huayro group 200 (GH200): with ulcer and treated with 200 mg/kg b.w. of S. tuberosum extract v.o., huayro group 400 (GH400): with ulcer and treated with 400 mg/kg b.w. of S. tuberosum extract v.o.. It was determined that the ethanolic extract of Solanum tuberosum L. "huayro" has a gastroprotective effect on gastric ulcers induced in Mus musculus BALB/c.
The objective of the research was to determine the effect of ethanolic extract of Solanum tuberosum L. "huayro" on induced gastric ulcer in Mus musculus BALB/c. The ethanolic extract of Solanum tuberosum ecotype "huayro" tuber peel was obtained with 96% acid ethanol (HCl) at pH 3; seven groups of five female mice each were induced with gastric ulceration with 50 mg indomethacin/kg body weight (b.w.) orally (v.o.), with the exception of the negative control group; the groups were: Negative Control Group (GCNG): no ulcer and 0.5 mL physiological saline solution (PSS) v.o., Positive Control Group (GCPS): with ulcer and with 0.5 mL SSF v.o., Standard Ranitidine Group (GERN): with ulcer and treated with 50 mg/kg b.w. ranitidine v.o., Standard omeprazole group (GEOM): with ulcer and treated with 50 mg/kg b.w. omeprazole v.o., Huayro group 100 (GH100): with ulcer and treated with 100 mg/kg b.w. S. tuberosum extract v.o., Huayro group 200 (GH200): with ulcer and treated with 200 mg/kg b.w. of S. tuberosum extract v.o., huayro group 400 (GH400): with ulcer and treated with 400 mg/kg b.w. of S. tuberosum extract v.o.. It was determined that the ethanolic extract of Solanum tuberosum L. "huayro" has a gastroprotective effect on gastric ulcers induced in Mus musculus BALB/c.
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Úlcera gástrica