Efecto de una pomada de extracto etanólico de Desmodium molliculum sobre herida en piel de Mus musculus BALB/c
No Thumbnail Available
Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Nacional de Trujillo
Abstract
La piel es órgano más extenso del cuerpo y se encuentra expuesta a ser el blanco de agentes patógenos, agresiones mecánicas o químicas, las cuales causan heridas. El objetivo de esta investigación fue determinar el efecto de una pomada a base de extracto etanólico de Desmodium molliculum sobre herida en piel de Mus musculus BALB/c. Se obtuvo el extracto con el cual se elaboró una pomada al 1% y 2%. Se usaron 54 ratones macho aleatoriamente distribuidos en 6 grupos: control positivo (GCP), con herida y sin tratamiento; pomada base (GPB), con herida y tratado con pomada base; estándar farmacológico ungüento antibiótico (GEF-UA), con herida y tratado con ungüento comercial (MULTYMICIN); estándar farmacológico ácido retinoico (GEF-AR), con herida y tratado con crema comercial que contiene ácido retinoico; experimental 1% (GDM1%), con herida y tratado con pomada a base de extracto etanólico de D. molliculum al 1%; experimental 2% (GDM2%), con herida y tratado con pomada a base de extracto etanólico de D. molliculum al 2%; los resultados obtenidos del proceso de cicatrización se sometieron a la prueba ANOVA y Tukey (ambas con 95% de confianza). Al día 12 los grupos GEF-UA, GEF-AR Y GDM1% ya habían cicatrizado totalmente y a nivel histológico en GDM2%, la longitud del tejido cicatricial era mínima. La pomada al 1 y 2% a base de extracto etanólico de Desmodium molliculum poseen efecto acelerador de la cicatrización y disminuye el tejido cicatricial a nivel histológico, respectivamente
The skin is the largest organ of the body and is exposed to being the target of pathogens, mechanical or chemical attacks, which cause wounds. The objective of this research was to determine the effect of an ointment based on ethanolic extract of Desmodium molliculum on wound skin of Mus musculus BALB/c. The extract was obtained with which a 1% and 2% ointment was made. Fifty four male mice were used randomly distributed into 6 groups: positive control (GCP), with wound and without treatment; base ointment (GPB), with wound and treated with base ointment; standard pharmacological antibiotic ointment (GEF-UA), with wound and treated with commercial ointment (MULTYMICIN); pharmacological standard retinoic acid (GEF-AR), with wound and treated with commercial cream containing retinoic acid; experimental 1% (GDM1%), with wound and treated with ointment based on 1% ethanolic extract of D. molliculum; experimental 2% (GDM2%), with wound and treated with ointment based on 2% ethanolic extract of D. molliculum; The results obtained from the healing process were subjected to the ANOVA and Tukey tests (both with 95% confidence). On day 12, the GEF-UA, GEF-AR and GDM1% groups had already completely healed and at the histological level in GDM2%, the length of scar tissue was minimal. The 1 and 2% ointment based on ethanolic extract of Desmodium molliculum has an accelerating effect on healing and reduces scar tissue at a histological level, respectively.
The skin is the largest organ of the body and is exposed to being the target of pathogens, mechanical or chemical attacks, which cause wounds. The objective of this research was to determine the effect of an ointment based on ethanolic extract of Desmodium molliculum on wound skin of Mus musculus BALB/c. The extract was obtained with which a 1% and 2% ointment was made. Fifty four male mice were used randomly distributed into 6 groups: positive control (GCP), with wound and without treatment; base ointment (GPB), with wound and treated with base ointment; standard pharmacological antibiotic ointment (GEF-UA), with wound and treated with commercial ointment (MULTYMICIN); pharmacological standard retinoic acid (GEF-AR), with wound and treated with commercial cream containing retinoic acid; experimental 1% (GDM1%), with wound and treated with ointment based on 1% ethanolic extract of D. molliculum; experimental 2% (GDM2%), with wound and treated with ointment based on 2% ethanolic extract of D. molliculum; The results obtained from the healing process were subjected to the ANOVA and Tukey tests (both with 95% confidence). On day 12, the GEF-UA, GEF-AR and GDM1% groups had already completely healed and at the histological level in GDM2%, the length of scar tissue was minimal. The 1 and 2% ointment based on ethanolic extract of Desmodium molliculum has an accelerating effect on healing and reduces scar tissue at a histological level, respectively.
Description
Keywords
Desmodium molliculum, herida, cicatrización