Características clínico-patológicas asociadas a sobrevida libre de recurrencia en pacientes con cáncer de cérvix en IREN Norte
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Date
2025-01-17
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Universidad Nacional de Trujillo
Abstract
Evaluar las características clínico-patológicas asociadas a sobrevida libre de recurrencia (SLR) en pacientes que padecen de cáncer de cérvix y que han recibido y culminado su tratamiento en el Instituto Regional de Enfermedades Neoplásicas (IREN) - Norte, durante en el periodo 2018 – 2019.
Métodos: Estudio de tipo observacional, retrospectivo y analítico de tipo cohorte. Se recopilaron datos 230 pacientes con cáncer de cérvix, considerando variables como tipo histológico, estadio patológico, tamaño tumoral y compromiso ganglionar. Los factores asociados se evaluaron empleando modelos de regresión de Cox y se presentaron los Hazzard Ratios (HR) como medida de asociación.
Resultados: La edad promedio fue de 49,12. La SLR fue del 58,69%. La edad avanzada (HR: 0,72–0,53; p < 0,01), estadios tumorales avanzados (HR: 0,45; p < 0,001), compromiso ganglionar paraaórtico (HR: 0,58; p = 0,005) y mayor tamaño tumoral (HR: 0,82; p = 0,039) se asociaron con menor SLR. En contraste, la radioterapia (HR: 1,23; p = 0,035), quimioterapia (HR: 1,32; p = 0,018) y cirugía (HR: 1,25; p = 0,028) mejoraron significativamente este desenlace.
Conclusión: La edad avanzada, estadios tumorales avanzados, compromiso ganglionar y mayor tamaño tumoral disminuye la sobrevida libre de recurrencia, mientras que tratamientos como radioterapia, quimioterapia y cirugía la mejoraron.
Palabras clave: Cáncer de cérvix; Sobrevida libre de recurrencia; Factores pronósticos.
Abstract To identify the clinical-pathological characteristics associated with recurrence-free survival (RFS) in patients with cervical cancer who have received and completed their treatment at the Regional Institute of Neoplastic Diseases (IREN) - North, during the period 2018 - 2019. Methods: Observational, retrospective and analytical cohort study. Data were collected from 230 patients with cervical cancer, considering variables such as histological type, pathological stage, tumor size and lymph node involvement. Associated factors were evaluated using Cox regression models and Hazzard Ratios (HR) were presented as a measure of association. Results: The average age was 49.12. RFS was 58.69%. Advanced age (HR: 0.72–0.53; p < 0.01), advanced tumor stages (HR: 0.45; p < 0.001), para-aortic lymph node involvement (HR: 0.58; p = 0.005) and larger tumor size (HR: 0.82; p = 0.039) were associated with lower RFS. In contrast, radiotherapy (HR: 1.23; p = 0.035), chemotherapy (HR: 1.32; p = 0.018) and surgery (HR: 1.25; p = 0.028) significantly improved this outcome. Conclusion: Advanced age, advanced tumour stages, lymph node involvement and larger tumour size decreased recurrence-free survival, while treatments such as radiotherapy, chemotherapy and surgery improved it.
Abstract To identify the clinical-pathological characteristics associated with recurrence-free survival (RFS) in patients with cervical cancer who have received and completed their treatment at the Regional Institute of Neoplastic Diseases (IREN) - North, during the period 2018 - 2019. Methods: Observational, retrospective and analytical cohort study. Data were collected from 230 patients with cervical cancer, considering variables such as histological type, pathological stage, tumor size and lymph node involvement. Associated factors were evaluated using Cox regression models and Hazzard Ratios (HR) were presented as a measure of association. Results: The average age was 49.12. RFS was 58.69%. Advanced age (HR: 0.72–0.53; p < 0.01), advanced tumor stages (HR: 0.45; p < 0.001), para-aortic lymph node involvement (HR: 0.58; p = 0.005) and larger tumor size (HR: 0.82; p = 0.039) were associated with lower RFS. In contrast, radiotherapy (HR: 1.23; p = 0.035), chemotherapy (HR: 1.32; p = 0.018) and surgery (HR: 1.25; p = 0.028) significantly improved this outcome. Conclusion: Advanced age, advanced tumour stages, lymph node involvement and larger tumour size decreased recurrence-free survival, while treatments such as radiotherapy, chemotherapy and surgery improved it.
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Keywords
Cáncer de Cérvix, Sobrevida Libre de Recurrencia, Factores Pronósticos