Alteración del perfil hepático como factor pronóstico de desenlaces obstétricos adversos en gestantes con preeclampsia en el Hospital Belén de Trujillo, periodo Enero 2017 – Diciembre 2022
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Date
2023-05-19
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Universidad Nacional de Trujillo
Abstract
La preeclampsia es un trastorno complejo, multiorgánico y progresivo del embarazo que generalmente se define como hipertensión más proteinuria después de las 20 semanas de gestación pudiendo presentar características de severidad que incluyen: presión arterial sistólica ≥ 160 mmHg o presión arterial diastólica ≥ 110 mmHg medidas en dos ocasiones con al menos 4 horas de diferencia; alteración de la función hepática; insuficiencia renal progresiva; trombocitopenia; edema pulmonar; y trastornos cerebrales o visuales de nueva aparición. Las anomalías hepáticas en el contexto de preeclampsia pueden ocurrir y son debido a la vasoconstricción que conduce a la reducción del flujo sanguíneo hepático y la eventual isquemia del parénquima; las pruebas hepáticas anormales en el segundo o tercer trimestre junto con hipertensión y proteinuria son altamente sugestivas de PE. Los niveles de aminotransferasa son anormales en 20% a 30% de los casos (≥2 veces al valor superior normal) Objetivo: Determinar si la alteración del perfil hepático es factor pronóstico de desenlaces obstétricos adversos en gestantes con preeclampsia en el Hospital Belén de Trujillo, periodo Enero 2017 – Diciembre 2022. Método: Este estudio corresponde a un diseño Analítico, observacional, prospectivo, de cohorte. En la que la población se dividió en dos: expuestos y no expuestos analizándose la frecuencia de desenlaces obstétricos adversos en gestantes con preeclampsia con o sin alteración del perfil hepático. Conclusión: La alteración del perfil hepático es factor pronóstico de desenlaces obstétricos adversos en gestantes con preeclampsia en el Hospital Belén de Trujillo, periodo Enero 2017 – Diciembre 2022.
Preeclampsia is a complex, multiorgan and progressive disorder of pregnancy that is generally defined as hypertension plus proteinuria after 20 weeks of gestation and may present severity characteristics that include: systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 110 mmHg. measured on two occasions at least 4 hours apart; impaired liver function; progressive kidney failure; thrombocytopenia; pulmonary edema; and new-onset brain or visual disorders. Liver abnormalities in the setting of preeclampsia can occur and are due to vasoconstriction leading to reduced hepatic blood flow and eventual parenchymal ischemia; Abnormal liver tests in the second or third trimester along with hypertension and proteinuria are highly suggestive of PE. Aminotransferase levels are abnormal in 20% to 30% of cases (≥2 times the upper normal value). Objective: To determine whether the alteration of the liver profile is a prognostic factor for adverse obstetric outcomes in pregnant women with preeclampsia at the Belén Hospital in Trujillo, period January 2017 – December 2022. Method: This study corresponds to an Analytical, observational, prospective, cohort design. In which the population was divided into two: exposed and unexposed, analyzing the frequency of adverse obstetric outcomes in pregnant women with preeclampsia with or without alteration of the liver profile. Conclusion: The alteration of the liver profile is a prognostic factor for adverse obstetric outcomes in pregnant women with preeclampsia at the Belén Hospital in Trujillo, period January 2017 – December 2022.
Preeclampsia is a complex, multiorgan and progressive disorder of pregnancy that is generally defined as hypertension plus proteinuria after 20 weeks of gestation and may present severity characteristics that include: systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 110 mmHg. measured on two occasions at least 4 hours apart; impaired liver function; progressive kidney failure; thrombocytopenia; pulmonary edema; and new-onset brain or visual disorders. Liver abnormalities in the setting of preeclampsia can occur and are due to vasoconstriction leading to reduced hepatic blood flow and eventual parenchymal ischemia; Abnormal liver tests in the second or third trimester along with hypertension and proteinuria are highly suggestive of PE. Aminotransferase levels are abnormal in 20% to 30% of cases (≥2 times the upper normal value). Objective: To determine whether the alteration of the liver profile is a prognostic factor for adverse obstetric outcomes in pregnant women with preeclampsia at the Belén Hospital in Trujillo, period January 2017 – December 2022. Method: This study corresponds to an Analytical, observational, prospective, cohort design. In which the population was divided into two: exposed and unexposed, analyzing the frequency of adverse obstetric outcomes in pregnant women with preeclampsia with or without alteration of the liver profile. Conclusion: The alteration of the liver profile is a prognostic factor for adverse obstetric outcomes in pregnant women with preeclampsia at the Belén Hospital in Trujillo, period January 2017 – December 2022.
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Keywords
Preeclampsia, Pruebas de Función Hepática, Embarazo de Alto Riesgo, Pronóstico