Caracterización de formas cristalinas de rifampicina 300 mg en cápsulas por calorimetría diferencial de barrido
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Date
2021
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Universidad Nacional de Trujillo
Abstract
El presente trabajo tuvo por objetivo caracterizar formas cristalinas de rifampicina 300 mg en capsulas mediante calorimetría diferencial de barrido convencional y de temperatura modulada; para lo cual se utilizó un calorímetro diferencial de barrido en el rango de 40 a 300 °C, con rampa de calentamiento de 10 °C/min y flujo de nitrógeno de 50 mL/min, el material de estudio fue estándar secundario de rifampicina y capsulas de rifampicina 300 mg de un medicamento referente y de 2 multifuentes, Las curvas DSC del estándar y del medicamento referente muestras a 185 °C el inicio de la transición solido liquido solido de la forma II (metaestable) a la forma I (estable) de rifampicina. El análisis por DSC de temperatura modulada evidencia eventos superpuestos en ambos medicamentos multifuentes, debido a la presencia de material amorfo de rifampicina a la misma temperatura de transición de la forma II a la forma I
ABSTRACT The objective of the present work was to characterize crystalline forms of rifampicin 300 mg in capsules by means of conventional and temperature- modulated differential scanning calorimetry; For which a differential scanning calorimeter was used in the range of 40 to 300 ° C, with a heating ramp of 10 ° C / min and a nitrogen flow of 50 mL / min, the study material was a secondary standard of rifampicin and rifampicin capsules 300 mg of a reference drug and 2 multi-sources, The DSC curves of the standard and the reference drug show at 185 ° C the beginning of the transition solid liquid solid from form II (metastable) to form I (stable) rifampicin. The DSC analysis of modulated temperature shows overlapping events in both multi-source drugs, due to the presence of amorphous rifampicin material at the same transition temperature from form II to form I.
ABSTRACT The objective of the present work was to characterize crystalline forms of rifampicin 300 mg in capsules by means of conventional and temperature- modulated differential scanning calorimetry; For which a differential scanning calorimeter was used in the range of 40 to 300 ° C, with a heating ramp of 10 ° C / min and a nitrogen flow of 50 mL / min, the study material was a secondary standard of rifampicin and rifampicin capsules 300 mg of a reference drug and 2 multi-sources, The DSC curves of the standard and the reference drug show at 185 ° C the beginning of the transition solid liquid solid from form II (metastable) to form I (stable) rifampicin. The DSC analysis of modulated temperature shows overlapping events in both multi-source drugs, due to the presence of amorphous rifampicin material at the same transition temperature from form II to form I.
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Keywords
Calorimetría diferencial de barrido. Temperatura modulada. Rifampicina. Formas cristalinas