Efecto del liofilizado del fruto de Vaccinium corymbosum L. sobre depresión, ansiedad y dolor inducido en Ratus norvegicus var Holtzman
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Date
2024
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Universidad Nacional de Trujillo
Abstract
La crisis de la salud mental, se ha exacerbado con el brote global del coronavirus, observándose aumento tanto de la ansiedad y depresión. En esta investigación se busca evaluar el efecto del liofilizado del fruto de Vaccinium corymbosum L. (ELVC), sobre la depresión, ansiedad y dolor en Rattus norvegicus var Holtzman. Se emplearon pruebas específicas como la prueba de Nado Forzado (Test de Porsolt), el laberinto en cruz elevado, y el modelo de Hot Plate, para la determinación sobre la depresión, ansiedad y el dolor inducido respectivamente. Se utilizaron dosis de 100 y 200 mg/kg del liofilizado del del fruto de Vaccinium corymbosum L por vía oral durante 21 días. Se llevó a cabo un análisis estadístico utilizando ANOVA y la prueba de Bonferroni. Los resultados mostraron que ELVC en dosis de 100 y 200 mg/kg, en la prueba del nado forzado (horizontal) tuvo un tiempo de nado promedio de 287,4 y 293 segundos respectivamente frente al grupo control 225,25 segundos, en la prueba de nado forzado (inmovilidad), tuvo un tiempo de inmovilidad de 2,8 y 1,9 segundos respectivamente frente al grupo control 11, 6 segundos. En la prueba del laberinto en cruz elevado, los brazos abiertos, la permanencia para el grupo problema para la dosis de 100 mg/kg y 200 mg/kg de arándano fue de 4,8 y 2,6 segundos respectivamente frente al grupo control de 7,5 segundos. En la prueba del Hot Plate se evidenció que la dosis de 100 mg/kg y 200 mg/kg del ELVC, tuvo un tiempo máximo de analgesia de 4,5 y 4,4 segundos respectivamente frente al grupo control 2,5 segundos. En conclusión, los resultados muestran que, el liofilizado del fruto de Vaccinium corymbosum L. posee propiedades antidepresivas y antinociceptivas.
The mental health crisis has been exacerbated by the global coronavirus outbreak, with an increase in anxiety and depression observed. This research seeks to evaluate the effect of freeze-dried Vaccinium corymbosum L. (ELVC) fruit on depression, anxiety and pain in Rattus norvegicus var Holtzman. Specific tests were used, such as the Forced Swim test (Porsolt Test), the elevated plus maze, and the Hot Plate model, to determine depression, anxiety, and induced pain, respectively. Doses of 100 and 200 mg/kg of the lyophilized fruit of Vaccinium corymbosum L were used orally for 21 days. Statistical analysis was carried out using ANOVA and the Bonferroni test. The results showed that ELVC at doses of 100 and 200 mg/kg, in the forced swim test (horizontal) had an average swimming time of 287,4 and 293 seconds respectively compared to the control group 225,25 seconds, in the test forced swimming (immobility), had an immobility time of 2,8 and 1,9 seconds respectively compared to the control group 11,6 seconds. In the elevated plus maze test, open arms, the permanence for the problem group for the dose of 100 mg/kg and 200 mg/kg of cranberry was 4,8 and 2,6 seconds respectively compared to the control group of 7,5 seconds. In the Hot Plate test it was evident that the dose of 100 mg/kg and 200 mg/kg of ELVC had a maximum analgesia time of 4,5 and 4.4 seconds respectively compared to the control group of 2,5 seconds. In conclusion, the results show that the lyophilized fruit of Vaccinium corymbosum L. has antidepressant and antinociceptive properties.
The mental health crisis has been exacerbated by the global coronavirus outbreak, with an increase in anxiety and depression observed. This research seeks to evaluate the effect of freeze-dried Vaccinium corymbosum L. (ELVC) fruit on depression, anxiety and pain in Rattus norvegicus var Holtzman. Specific tests were used, such as the Forced Swim test (Porsolt Test), the elevated plus maze, and the Hot Plate model, to determine depression, anxiety, and induced pain, respectively. Doses of 100 and 200 mg/kg of the lyophilized fruit of Vaccinium corymbosum L were used orally for 21 days. Statistical analysis was carried out using ANOVA and the Bonferroni test. The results showed that ELVC at doses of 100 and 200 mg/kg, in the forced swim test (horizontal) had an average swimming time of 287,4 and 293 seconds respectively compared to the control group 225,25 seconds, in the test forced swimming (immobility), had an immobility time of 2,8 and 1,9 seconds respectively compared to the control group 11,6 seconds. In the elevated plus maze test, open arms, the permanence for the problem group for the dose of 100 mg/kg and 200 mg/kg of cranberry was 4,8 and 2,6 seconds respectively compared to the control group of 7,5 seconds. In the Hot Plate test it was evident that the dose of 100 mg/kg and 200 mg/kg of ELVC had a maximum analgesia time of 4,5 and 4.4 seconds respectively compared to the control group of 2,5 seconds. In conclusion, the results show that the lyophilized fruit of Vaccinium corymbosum L. has antidepressant and antinociceptive properties.
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HUMANITIES and RELIGION::History and philosophy subjects::History subjects::History