Cociente BUN/Creatinina como predictor de ingreso a Unidad de Cuidados Intensivos en pacientes hospitalizados con COVID-19
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Date
2024-02-06
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Universidad Nacional de Trujillo
Abstract
La pandemia del COVID-19 estableció una mayor demanda de las unidades de cuidado de intensivo (UCI), siendo necesario la implementación de marcadores predictivos de severidad y mortalidad.
OBJETIVO: Demostrar que el BUN/Creatinina es un predictor de ingreso a UCI en pacientes con COVID-19 en el Hospital Regional Docente de Trujillo (HRDT).
MATERIALES Y MÉTODOS: Estudio observacional analítico retrospectivo, de pruebas diagnósticas. Se seleccionaron 385 historias clínicas de pacientes con COVID-19 en el HRDT durante los años 2020 y 2021 para la recolección de datos.
RESULTADOS: De 385 pacientes, el 39.22% de pacientes cumplían con los criterios de ingreso a UCI, se descartó asociación con otras variables como edad (p=0.090), género (p=0.545) y comorbilidades (p=0.260), el punto de corte óptimo del BUN/Creatinina fue 29.01, asociándose significativamente (p< 0.00001) con el ingreso a UCI con una sensibilidad, especificidad, VPP y VPN del 67.55%, 73.08%, 61.82% y 77.73%, respectivamente. La curva ROC obtuvo el AUC de 71.97%.
CONCLUSIONES: El cociente BUN/Creatinina ≥ 29.01 es un predictor de nivel intermedio para el ingreso a UCI (p< 0.00001).
Abstract The COVID-19 pandemic established a greater demand for intensive care units (ICU), being necessary the implementation of predictive markers of severity and mortality. OBJECTIVE: To demonstrate that BUN/Creatinine is a predictor of ICU admission in patients with COVID-19 in the Hospital Regional Docente de Trujillo (HRDT). MATERIALS AND METHODS: Retrospective analytical observational study of diagnostic tests. A total of 385 medical records of patients with COVID-19 at HRDT during the years 2020 and 2021 were selected for data collection. RESULTS: Out of 385 patients, 39.22% of patients met the criteria for ICU admission, association with other variables such as age (p=0.090), gender (p=0.545) and comorbidities (p=0. 260), the optimal cut-off point of BUN/Creatinine was 29.01, being significantly associated (p<0.00001) with admission to ICU with a sensitivity, specificity, PPV and NPV of 67.55%, 73.08%, 61.82% and 77.73%, respectively. ROC curve obtained the AUC of 71.97%. CONCLUSIONS: BUN/Creatinine ratio ≥ 29.01 is an intermediate level predictor for ICU admission (p< 0.00001).
Abstract The COVID-19 pandemic established a greater demand for intensive care units (ICU), being necessary the implementation of predictive markers of severity and mortality. OBJECTIVE: To demonstrate that BUN/Creatinine is a predictor of ICU admission in patients with COVID-19 in the Hospital Regional Docente de Trujillo (HRDT). MATERIALS AND METHODS: Retrospective analytical observational study of diagnostic tests. A total of 385 medical records of patients with COVID-19 at HRDT during the years 2020 and 2021 were selected for data collection. RESULTS: Out of 385 patients, 39.22% of patients met the criteria for ICU admission, association with other variables such as age (p=0.090), gender (p=0.545) and comorbidities (p=0. 260), the optimal cut-off point of BUN/Creatinine was 29.01, being significantly associated (p<0.00001) with admission to ICU with a sensitivity, specificity, PPV and NPV of 67.55%, 73.08%, 61.82% and 77.73%, respectively. ROC curve obtained the AUC of 71.97%. CONCLUSIONS: BUN/Creatinine ratio ≥ 29.01 is an intermediate level predictor for ICU admission (p< 0.00001).
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Keywords
COVID-19, Nitrógeno de la Urea Sanguínea, Creatinina, Unidades de Cuidados Intensivos