Correlación del sistema sanguíneo ABO con la susceptibilidad a COVID -19 en la población del distrito de Casa Grande, Ascope – La Libertad -2020
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Date
2022
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Universidad Nacional de Trujillo
Abstract
La infección causada por el coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2), llamada enfermedad por coronavirus 2019 (COVID-19), ha cobrado la vida de más de 5,2 millones de personas debidas al virus y existen más de 256,5 millones de casos confirmados de COVID-19 en todo el mundo. En los últimos días ha crecido un interés en conocer si los antígenos del sistema sanguíneo ABO tienen un papel en la susceptibilidad de infección por SARSCoV-2 o en la Gravedad de La enfermedad. Debido a que los antígenos del sistema ABO se han asociado a otro tipo de enfermedades, como la diabetes, asma, neumonía, hipercolesterolemia, cirrosis hepáticas, cáncer y fibrosis pulmonar. Esta investigación demostró la correlación del sistema sanguíneo ABO con la susceptibilidad a COVID -19 en la población del distrito de Casa Grande, Ascope – La Libertad 2020. Se trabajó con un total de 100 muestras de sangre de personas infectadas con Covid -19 en el distrito de Casa Grande, bajo el criterio de participación voluntaria y se utilizó una muestra de sangre con anticoagulante EDTA, para la tipificación directa ABO. Teniendo como resultado la distribución de frecuencias entre grados del progreso de la enfermedad con el grupo sanguíneo A; existen diferencias significativas, en todos los casos, como lo demuestra el Test de proporciones, a un nivel de confianza del 95 %. En revisión, el 34% de personas en la misma región tienen sangre del Grupo O, los pacientes representaron sólo 26% de los casos y también muertes. Existen diferencias altamente significativas en todos los casos (nivel de confianza de 99 %) entre los valores del Ji cuadrado calculado y tabulado, al comparar progreso de la enfermedad con grupo sanguíneo, existiendo una fuerte asociación entre estas dos variables; confirmado por los valores de correlación (r = -0.364; Rho = -0.181); de tal modo que el grupo sanguíneo A predomina en los grados crítico y severo (o muerte) de la enfermedad; mientras que, en los grados leve y moderado, predominan los otros grupos sanguíneos
The infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), called coronavirus disease 2019 (COVID-19), has claimed the lives of more than 5.2 million people due to the virus and there are more of 256.5 million confirmed cases of COVID-19 worldwide. In recent days, there has been a growing interest in knowing if the ABO blood system antigens have a role in the susceptibility of SARSCoV-2 infection or in the severity of the disease. Because the ABO system antigens have been associated with other types of diseases, such as diabetes, asthma, pneumonia, hypercholesterolemia, liver cirrhosis, cancer and pulmonary fibrosis. This research demonstrated the correlation of the ABO blood system with susceptibility to COVID -19 in the population of the district of Casa Grande, Ascope - La Libertad 2020. A total of 100 blood samples from people infected with Covid -19 were worked on in the Casa Grande district, under the criterion of voluntary participation and a blood sample with EDTA anticoagulant was used for direct ABO typing. Having as a result the distribution of frequencies between degrees of the progress of the disease with blood group A; There are significant differences, in all cases, as shown by the Test of proportions, at a confidence level of 95%. On review, 34% of people in the same region have Group O blood, patients accounted for only 26% of cases and also deaths. There are highly significant differences in all cases (99% confidence level) between the calculated and tabulated Chi square values, when comparing disease progress with blood group, with a strong association between these two variables; confirmed by the correlation values (r = -0.364; Rho = -0.181); in such a way that blood group A predominates in the critical and severe degrees (or death) of the disease; while, in mild and moderate degrees, the other blood groups predominate
The infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), called coronavirus disease 2019 (COVID-19), has claimed the lives of more than 5.2 million people due to the virus and there are more of 256.5 million confirmed cases of COVID-19 worldwide. In recent days, there has been a growing interest in knowing if the ABO blood system antigens have a role in the susceptibility of SARSCoV-2 infection or in the severity of the disease. Because the ABO system antigens have been associated with other types of diseases, such as diabetes, asthma, pneumonia, hypercholesterolemia, liver cirrhosis, cancer and pulmonary fibrosis. This research demonstrated the correlation of the ABO blood system with susceptibility to COVID -19 in the population of the district of Casa Grande, Ascope - La Libertad 2020. A total of 100 blood samples from people infected with Covid -19 were worked on in the Casa Grande district, under the criterion of voluntary participation and a blood sample with EDTA anticoagulant was used for direct ABO typing. Having as a result the distribution of frequencies between degrees of the progress of the disease with blood group A; There are significant differences, in all cases, as shown by the Test of proportions, at a confidence level of 95%. On review, 34% of people in the same region have Group O blood, patients accounted for only 26% of cases and also deaths. There are highly significant differences in all cases (99% confidence level) between the calculated and tabulated Chi square values, when comparing disease progress with blood group, with a strong association between these two variables; confirmed by the correlation values (r = -0.364; Rho = -0.181); in such a way that blood group A predominates in the critical and severe degrees (or death) of the disease; while, in mild and moderate degrees, the other blood groups predominate
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Keywords
Coronavirus, COVID – 19, ABO