Cinética de los anticuerpos IgG e IgM anti-citomegalovirus después del nacimiento
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Date
2022
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Universidad Nacional de Trujillo
Abstract
El citomegalovirus (CMV) es un patógeno viral prevalente, en la mayoría de las personas con CMV agudo experimentan una infección inaparente. La fuente principal de infección primaria por CMV ocurre durante el embarazo y en el primer año de vida. El objetivo del presente trabajo fue determinar la cinética de los anticuerpos IgG e IgM anti-citomegalovirus después del nacimiento. Se analizó un total de 90 individuos, conformado por 20 madres con sus recién nacidos y 50 niños menores de un año, atendidos en el Hospital Santa María de Cutervo. La medición de los niveles de IgG e IgM anti-citomegalovirus, fue por la técnica de inmunoquimioluminiscencia, además se realizó una encuesta para conocer datos epidemiológicos. Los niveles de anticuerpos entre las madres y los recién nacidos se mantienen en niveles similares. En los IgG, se observa una disminución de los niveles de anticuerpo desde el momento del nacimiento hasta los 9 meses de edad, después se muestra un aumento hasta los 12 meses. La dispersión por edades de los niveles de IgG e IgM anti-citomegalovirus en niños menores de 1 año, se observa que los niveles IgG está en niveles altos en todos los grupos, señalando una positividad del 97%. En cambio, los niveles de IgM se mantienen bajos dando una positividad de solo 2.8% del total de los niños analizados. Se determinó la cinética de los anticuerpos IgG e IgM anti-citomegalovirus después del nacimiento, donde su respuesta humoral con respecto al IgG durante el primer año de vida, evidencia que se encuentra en concentraciones elevadas después del nacimiento y continua con una disminución de los niveles de anticuerpos hasta los 9 meses, posterior a esto, se da un aumento de su concentración hasta los 12 meses. La cinética del anticuerpo IgM anti-citomegalovirus aparece con la respuesta humoral en el primer año de vida, donde sus concentraciones se elevaron en respuesta a la infección con el citomegalovirus entre el primer y tercer trimestre después del nacimiento.
Cytomegalovirus (CMV) is a prevalent viral pathogen; most persons with acute CMV experience inapparent infection. The main source of primary CMV infection occurs during pregnancy and in the first year of life. The aim of the present work was to determine the kinetics of anti-cytomegalovirus IgG and IgM antibodies after birth. A total of 90 individuals were analyzed, comprising 20 mothers with their newborns and 50 children under one year of age attended at the Hospital Santa María de Cutervo. Anti-cytomegalovirus IgG and IgM levels were measured by immunochemiluminescence technique, and a survey was carried out to obtain epidemiological data. The levels of antibodies between mothers and newborns remained at similar levels. In IgG, a decrease in antibody levels was observed from the time of birth until 9 months of age, after which an increase was observed until 12 months of age. The dispersion by age of IgG and IgM anti-cytomegalovirus levels in children under 1 year of age shows that IgG levels are at high levels in all groups, indicating a positivity of 97%. On the other hand, IgM levels remained low, giving a positivity of only 2.8% of the total number of children analyzed. The kinetics of anti-cytomegalovirus IgG and IgM antibodies were determined after birth, where their humoral response with respect to IgG during the first year of life, evidence that it is found in high concentrations after birth and continues with a decrease in antibody levels until 9 months, after this, there is an increase in its concentration until 12 months. The kinetics of anti-cytomegalovirus IgM antibody appears with the humoral response in the first year of life, where its concentrations rose in response to cytomegalovirus infection between the first and third trimester after birth.
Cytomegalovirus (CMV) is a prevalent viral pathogen; most persons with acute CMV experience inapparent infection. The main source of primary CMV infection occurs during pregnancy and in the first year of life. The aim of the present work was to determine the kinetics of anti-cytomegalovirus IgG and IgM antibodies after birth. A total of 90 individuals were analyzed, comprising 20 mothers with their newborns and 50 children under one year of age attended at the Hospital Santa María de Cutervo. Anti-cytomegalovirus IgG and IgM levels were measured by immunochemiluminescence technique, and a survey was carried out to obtain epidemiological data. The levels of antibodies between mothers and newborns remained at similar levels. In IgG, a decrease in antibody levels was observed from the time of birth until 9 months of age, after which an increase was observed until 12 months of age. The dispersion by age of IgG and IgM anti-cytomegalovirus levels in children under 1 year of age shows that IgG levels are at high levels in all groups, indicating a positivity of 97%. On the other hand, IgM levels remained low, giving a positivity of only 2.8% of the total number of children analyzed. The kinetics of anti-cytomegalovirus IgG and IgM antibodies were determined after birth, where their humoral response with respect to IgG during the first year of life, evidence that it is found in high concentrations after birth and continues with a decrease in antibody levels until 9 months, after this, there is an increase in its concentration until 12 months. The kinetics of anti-cytomegalovirus IgM antibody appears with the humoral response in the first year of life, where its concentrations rose in response to cytomegalovirus infection between the first and third trimester after birth.
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Keywords
IgG, IgM, Anticuerpos, Cinética, Citomegalovirus