Actividad antibacteriana in vitro de colutorios elaborados a base de Cannabidiol comparado con colutorios comerciales sobre S. Mutans ATCC 35668
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Date
2023
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Universidad Nacional de Trujillo
Abstract
Introducción: La evidencia científica respalda el uso del CBD y otros compuestos derivados del Cannabis en productos de higiene bucal como colutorios, ofreciendo alternativas naturales a los enjuagues comerciales y la clorhexidina. Objetivo: Comparar la actividad antibacteriana de preparados magistrales de colutorio a base de Cannabidiol con la de los colutorios comerciales sobre el Streptococcus mutans ATCC 35668 in vitro. Material y métodos: Se elaboraron dos colutorios con aceites esenciales de CBD al 20% de diferentes marcas. Se compararon con enjuagues comerciales de Trujillo usando una prueba de sensibilidad en agar Muller-Hinton. Se realizaron 16 observaciones por grupo, y se usó clorhexidina al 0,12% como control positivo y solución salina estéril como control negativo. Resultados: El colutorio de CBD 1 y el control negativo no mostraron sensibilidad ante el Streptococcus mutans ATCC 35668, mientras que el colutorio de CBD 2, el colutorio comercial 3 y la clorhexidina al 0,12% fueron muy sensibles. Los colutorios comerciales 1 y 2 tuvieron una sensibilidad reducida. El análisis estadístico no encontró diferencias significativas (p>0,05) entre el colutorio de CBD 2, el colutorio comercial 3 y la clorhexidina al 0,12%. Conclusiones: El colutorio de CBD al 20% fue altamente sensible al Streptococcus mutans ATCC 35668 y mostró resultados comparables a los del colutorio comercial 3 y la clorhexidina al 0,12%.
Introduction: Scientific evidence supports the use of CBD and other Cannabis-derived compounds in oral hygiene products like mouthwashes, providing natural alternatives to commercial mouthwashes and chlorhexidine. Objective: To compare the antibacterial activity of CBD-based compounded mouthwashes with commercial mouthwashes against Streptococcus mutans ATCC 35668 in vitro. Materials and Methods: Two mouthwashes were prepared using 20% CBD essential oils from different brands. They were compared to commercial mouthwashes in Trujillo using a sensitivity test on Muller-Hinton agar. Sixteen observations were made for each group, and 0.12% chlorhexidine was used as a positive control, with sterile saline solution as the negative control. Results: CBD mouthwash 1 and the negative control showed no sensitivity to Streptococcus mutans ATCC 35668, while CBD mouthwash 2, commercial mouthwash 3, and 0.12% chlorhexidine were highly sensitive. Commercial mouthwashes 1 and 2 had reduced sensitivity. The statistical analysis found no significant differences (p>0.05) between CBD mouthwash 2, commercial mouthwash 3, and 0.12% chlorhexidine. Conclusions: The 20% CBD mouthwash demonstrated high sensitivity to Streptococcus mutans ATCC 35668, yielding results comparable to those of commercial mouthwash 3 and 0.12% chlorhexidine.
Introduction: Scientific evidence supports the use of CBD and other Cannabis-derived compounds in oral hygiene products like mouthwashes, providing natural alternatives to commercial mouthwashes and chlorhexidine. Objective: To compare the antibacterial activity of CBD-based compounded mouthwashes with commercial mouthwashes against Streptococcus mutans ATCC 35668 in vitro. Materials and Methods: Two mouthwashes were prepared using 20% CBD essential oils from different brands. They were compared to commercial mouthwashes in Trujillo using a sensitivity test on Muller-Hinton agar. Sixteen observations were made for each group, and 0.12% chlorhexidine was used as a positive control, with sterile saline solution as the negative control. Results: CBD mouthwash 1 and the negative control showed no sensitivity to Streptococcus mutans ATCC 35668, while CBD mouthwash 2, commercial mouthwash 3, and 0.12% chlorhexidine were highly sensitive. Commercial mouthwashes 1 and 2 had reduced sensitivity. The statistical analysis found no significant differences (p>0.05) between CBD mouthwash 2, commercial mouthwash 3, and 0.12% chlorhexidine. Conclusions: The 20% CBD mouthwash demonstrated high sensitivity to Streptococcus mutans ATCC 35668, yielding results comparable to those of commercial mouthwash 3 and 0.12% chlorhexidine.
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Keywords
Streptococcus mutans, Cannabidiol, Enjuague bucal, Agente antibacteriano