Asociación del umbral de ciclos en RT-PCR para SARS-CoV-2, la severidad y mortalidad de COVID-19 en pacientes atendidos en el Hospital Regional Docente de Trujillo, La Libertad, enero– julio 2021.
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Date
2024
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Universidad Nacional de Trujillo
Abstract
El umbral de ciclos(Ct) de la prueba RT-PCR es un valor inversamente relacionado con la cantidad de ARN de la muestra y aún está en estudio su utilidad en la evolución de la enfermedad del COVID -19 que ha causado alta mortalidad a nivel Nacional y Mundial. Esta investigación retrospectiva de corte transversal buscó determinar si existe asociación del umbral de ciclos en RT-PCR para SARS-CoV-2, la severidad y mortalidad de la COVID-19 en pacientes atendidos en el Hospital Regional Docente de Trujillo, La Libertad, enero– julio 2021. Fueron evaluados los valores de Ct (>25 o ≤25), la severidad de la enfermedad (leve, moderado o severo) y la mortalidad en 260 pacientes a partir de sus registros clínicos, además se determinó su asociación con nivel de confianza de 95%. Se encontró una mortalidad de 39.6%. El 72.7%, el 25,8% y el 1.5% presentó la enfermedad en grado severo, moderado y leve respectivamente. El 59.2% presentó un Ct ≤ 25 y a la vez COVID-19 de grado severo. Pacientes con Ct ≤25 tienen una mortalidad de 33.8% y supervivencia de 41.9%. Se determinó asociación significativa entre el umbral de ciclos en RT-PCR para SARS-CoV-2, la severidad y la mortalidad de COVID -19 (p<0.005).
The Cycle Threshold (Ct) of the RT-PCR test is inversely related to the amount of RNA in the sample. It is still under study its usefulness in COVID-19 evolution disease that has caused high mortality levels at the National and World. This retrospective cross-sectional research sought to determine whether there is an association between the cycle threshold in RT-PCR for SARS-CoV-2, the severity and mortality of COVID-19 in patients treated at the Regional Teaching Hospital of Trujillo, La Libertad, January-July 2021. The Ct values (>25 or ≤25), the severity of the disease (mild, moderate, or severe), and mortality were evaluated from 260 patient’s clinical records and their association with a 95% confidence level was determined. Mortality was 39.6%. The 72.7%, 25.8%, and 1.5% presented the disease in severe, moderate, and mild degree respectively. The 59.2% presented a Ct ≤25 and COVID-19 of severe grade too. Patients with Ct ≤25 have a mortality of 33.8% and survival of 41.9%. Significant association was determined between the cycle threshold in RT-PCR for SARS-CoV-2, severity and mortality of COVID-19 (p<0.005).
The Cycle Threshold (Ct) of the RT-PCR test is inversely related to the amount of RNA in the sample. It is still under study its usefulness in COVID-19 evolution disease that has caused high mortality levels at the National and World. This retrospective cross-sectional research sought to determine whether there is an association between the cycle threshold in RT-PCR for SARS-CoV-2, the severity and mortality of COVID-19 in patients treated at the Regional Teaching Hospital of Trujillo, La Libertad, January-July 2021. The Ct values (>25 or ≤25), the severity of the disease (mild, moderate, or severe), and mortality were evaluated from 260 patient’s clinical records and their association with a 95% confidence level was determined. Mortality was 39.6%. The 72.7%, 25.8%, and 1.5% presented the disease in severe, moderate, and mild degree respectively. The 59.2% presented a Ct ≤25 and COVID-19 of severe grade too. Patients with Ct ≤25 have a mortality of 33.8% and survival of 41.9%. Significant association was determined between the cycle threshold in RT-PCR for SARS-CoV-2, severity and mortality of COVID-19 (p<0.005).
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Keywords
SARS-CoV-2, COVID - 19, Cycle Threshold (Ct), severidad y mortalidad.