Hígado graso no alcohólico como factor de riesgo para aterosclerosis carotídea en sujetos atendidos en el Hospital Víctor Lazarte Echegaray
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Date
2024-07-08
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Universidad Nacional de Trujillo
Abstract
La enfermedad ateroesclerótica es la principal causa de mortalidad en pacientes con hígado graso no alcohólico, esta asociación tiene implicaciones importantes para el cribado y la evaluación temprana de estos pacientes, lamentablemente suele ser asintomática en sus inicios. Actualmente existe ayuda diagnóstica no invasiva como el Doppler carotídeo.
HGNA es un factor de riesgo independiente, y se cree que desempeña un papel activo en la liberación sistémica de mediadores pro aterogénicos y proinflamatorios, con contribuciones adicionales como la resistencia a la insulina y perfiles lipídicos aterogénicos anormales, todo lo cual aumenta el riesgo de aterogénesis.
En estudios donde se evalúa la asociación entre la Esteatosis hepática no alcohólica y el desarrollo de placa en la arteria carótida describen que la prevalencia de esta placa fue significativamente mayor en participantes de edad avanzada con HGNA que en aquellos sin HGNA.
Abstract Atherosclerotic disease is the main cause of mortality in patients with non-alcoholic fatty liver. This association has important implications for the screening and early evaluation of these patients. Unfortunately, it is usually asymptomatic at the beginning. Currently there is non-invasive diagnostic aid such as carotid Doppler. NAFLD is an independent risk factor, and is believed to play an active role in the systemic release of pro-atherogenic and pro-inflammatory mediators, with additional contributions such as insulin resistance and abnormal atherogenic lipid profiles, all of which increase the risk of atherogenesis. . . In studies evaluating the association between non-alcoholic hepatic steatosis and the development of plaque in the carotid artery, it was described that the prevalence of this plaque was significantly higher in elderly participants with NAFLD than in those without NAFLD.
Abstract Atherosclerotic disease is the main cause of mortality in patients with non-alcoholic fatty liver. This association has important implications for the screening and early evaluation of these patients. Unfortunately, it is usually asymptomatic at the beginning. Currently there is non-invasive diagnostic aid such as carotid Doppler. NAFLD is an independent risk factor, and is believed to play an active role in the systemic release of pro-atherogenic and pro-inflammatory mediators, with additional contributions such as insulin resistance and abnormal atherogenic lipid profiles, all of which increase the risk of atherogenesis. . . In studies evaluating the association between non-alcoholic hepatic steatosis and the development of plaque in the carotid artery, it was described that the prevalence of this plaque was significantly higher in elderly participants with NAFLD than in those without NAFLD.
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Keywords
Enfermedad del Hígado Graso no Alcohólico, Aterosclerosis, Arteria Carótida, Doppler