Genotoxicidad en células de mucosa oral asociada al estado nutricional de escolares de Trujillo – 2024
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Date
2024-12-10
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Universidad Nacional de Trujillo
Abstract
Determinar la asociación entre la genotoxicidad en células de mucosa oral y el estado nutricional de escolares de Trujillo – 2024. Materiales y métodos: El diseño del estudio fue de tipo observacional, analítico, transversal y prospectivo. La muestra estuvo conformada por 48 escolares entre 6 y 11 años de la Institución Educativa N° 80031 Municipal, provincia de Trujillo, que se dividieron equitativamente en 2 grupos: normopeso y sobrepeso-obesidad; de todos ellos se obtuvo muestra de la parte interna de las mejillas para su posterior procesamiento a fin de determinar la genotoxicidad. Resultados: La frecuencia entre los grupos sobrepeso-obesidad y normopeso tuvo similitud, en relación a la frecuencia de micronúcleos en las células de mucosa oral en los escolares con sobrepeso-obesidad fue 22 ± 17; estableciéndose la asociación entre la genotoxicidad y el estado nutricional con una razón de prevalencia (RP) de 5,25. Conclusión: Los escolares de Trujillo con sobrepeso-obesidad presentaron mayor prevalencia de genotoxicidad en células de mucosa oral, lo que refleja asociación significativa entre genotoxicidad y estado nutricional.
Palabras clave: Genotoxicidad, estado nutricional, sobrepeso, obesidad, niños.
Abstract To determine the association between genotoxicity in oral mucosa cells and nutritional status of schoolchildren in Trujillo – 2024. Materials and methods: The study design was observational, analytical, cross-sectional and prospective. The sample consisted of 48 schoolchildren between 6 and 11 years old from the Educational Institution Nº 80031 Municipal, province of Trujillo, who were equally divided into 2 groups: normal weight and overweight-obesity; from all of them a sample was obtained from the inner part of the cheeks for later processing in order to determine genotoxicity. Results: The frequency between the overweight-obesity and normal weight groups was similar, in relation to the frequency of micronuclei in oral mucosa cells in schoolchildren with overweight-obesity was 22 ± 17; establishing the association between genotoxicity and nutritional status with a prevalence ratio (RP) of 5,25. Conclusion: The schoolchildren from Trujillo with overweight-obesity presented a higher prevalence of genotoxicity in oral mucosa cells, reflecting a significant association between genotoxicity and nutritional status.
Abstract To determine the association between genotoxicity in oral mucosa cells and nutritional status of schoolchildren in Trujillo – 2024. Materials and methods: The study design was observational, analytical, cross-sectional and prospective. The sample consisted of 48 schoolchildren between 6 and 11 years old from the Educational Institution Nº 80031 Municipal, province of Trujillo, who were equally divided into 2 groups: normal weight and overweight-obesity; from all of them a sample was obtained from the inner part of the cheeks for later processing in order to determine genotoxicity. Results: The frequency between the overweight-obesity and normal weight groups was similar, in relation to the frequency of micronuclei in oral mucosa cells in schoolchildren with overweight-obesity was 22 ± 17; establishing the association between genotoxicity and nutritional status with a prevalence ratio (RP) of 5,25. Conclusion: The schoolchildren from Trujillo with overweight-obesity presented a higher prevalence of genotoxicity in oral mucosa cells, reflecting a significant association between genotoxicity and nutritional status.
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Keywords
Genotoxicidad, Estado Nutricional, Sobrepeso, Obesidad, Niños