Acidosis y encefalopatía hipóxico isquémica moderada y severa en recién nacidos con depresión al nacer atendidos en el Hospital Belén de Trujillo
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Date
2022-12-08
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Universidad Nacional de Trujillo
Abstract
La encefalopatía hipóxico isquémica es un síndrome clínico de disfunción neurológica aguda que se presenta en los recién nacidos de mas de 35 semanas con asfixia desencadenada por un evento centinela. Episodios de exposición prolongada a eventos hipóxico isquémicos conllevará a un agotamiento energético en los tejidos que dependen exclusivamente del metabolismo aerobio como es el caso del SNC; lo cual producirá daños en la población celular más sensible del SNC que morirán por necrosis.
Se realizará un estudio observacional, correlacional, retrospectivo y de corte transversal en el Hospital Belén de Trujillo, con el objetivo de determinar si la acidosis está relacionada al desarrollo de encefalopatía hipóxico isquémica moderada y severa en recién nacidos con asfixia del hospital Belén de Trujillo. Se revisarán las historias clínicas de los neonatos con diagnóstico de depresión al nacer y se evaluará la presencia de acidosis en cada uno de los pacientes. Para establecer la relación que existe entre acidosis y encefalopatía hipóxico isquémica moderada y severa se utilizará la prueba estadística de Chi cuadrado
Hypoxic ischemic encephalopathy is a clinical syndrome of acute neurological dysfunction that occurs in newborns older than 35 weeks with asphyxia triggered by a sentinel event. Episodes of prolonged exposure to hypoxic-ischemic events will lead to energy depletion in tissues that depend exclusively on aerobic metabolism, such as the CNS; which will cause damage to the most sensitive cell population of the CNS that will die from necrosis. An observational, correlational, retrospective and cross-sectional study will be carried out at the Belén Hospital in Trujillo, with the objective of determining whether acidosis is related to the development of moderate and severe hypoxic ischemic encephalopathy in newborns with asphyxia at the Belén Hospital in Trujillo. The medical records of neonates with a diagnosis of depression at birth will be reviewed and the presence of acidosis will be evaluated in each of the patients. To establish the relationship between acidosis and moderate and severe hypoxic ischemic encephalopathy, the Chi square statistical test will be used.
Hypoxic ischemic encephalopathy is a clinical syndrome of acute neurological dysfunction that occurs in newborns older than 35 weeks with asphyxia triggered by a sentinel event. Episodes of prolonged exposure to hypoxic-ischemic events will lead to energy depletion in tissues that depend exclusively on aerobic metabolism, such as the CNS; which will cause damage to the most sensitive cell population of the CNS that will die from necrosis. An observational, correlational, retrospective and cross-sectional study will be carried out at the Belén Hospital in Trujillo, with the objective of determining whether acidosis is related to the development of moderate and severe hypoxic ischemic encephalopathy in newborns with asphyxia at the Belén Hospital in Trujillo. The medical records of neonates with a diagnosis of depression at birth will be reviewed and the presence of acidosis will be evaluated in each of the patients. To establish the relationship between acidosis and moderate and severe hypoxic ischemic encephalopathy, the Chi square statistical test will be used.
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Keywords
Encefalopatía isquémica, Asfixia Neonatal, Acidosis, Cordón Umbilical