Valor de la escala ultrasonográfica de 6 articulaciones en la predicción de remisión clínica en pacientes con artritis reumatoide del Hospital Regional Docente de Trujillo
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Date
2024-05-23
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Universidad Nacional de Trujillo
Abstract
La artritis reumatoide es una enfermedad inflamatoria crónica, que se caracteriza por afectación simétrica de las articulaciones de tamaño pequeño y mediano. Las lesiones patológicas se caracterizan por sinovitis persistente acompañado por hiperplasia sinovial con invasión hacia tejidos adyacentes y formación de pannus. La remisión clínica en artritis reumatoide se define como la ausencia de signos y síntomas de inflamación significativa, esto se logra con diagnóstico rápido y la respuesta a las modificaciones del tratamiento con una estrecha vigilancia y control. Sin embargo, la discrepancia entre la remisión clínica y la evidencia de deterioro estructural continuo ha llevado a postular la existencia de inflamación silenciosa persistente, también llamada inflamación subclínica. Por tanto, la ultrasonografía puede utilizarse para evaluar signos subclínicos de actividad inflamatoria, por ser más sensible que la evaluación clínica; permitiendo monitorizar la enfermedad por las características que aporta tanto, por la escala de grises como por el flujo Doppler. Objetivo: Determinar el valor de la escala ultrasonográfica de 6 articulaciones en la predicción de remisión clínica en pacientes con artritis reumatoide del Hospital Regional Docente de Trujillo. Material y Métodos: se desarrollará un estudio aplicado, analítico, transversal y prospectivo. La población, estarán conformado por pacientes con diagnóstico reciente de artritis reumatoide en el Servicio de Reumatología del Hospital Regional Docente de Trujillo en el periodo de febrero a abril 2024. Las estadísticas descriptivas serán presentadas en cuadros de entrada simple y doble. La estadística analítica se obtendrá con la curva ROC.
Abstract Rheumatoid arthitis is a chronic inflammatory disease, characterized by symmetrical involvement of small and médium sized joints. Pathological lesions are characterized by persistent sinovitis accompanied by synovial hyperplasia with invasion into adjacent tissues and pannus formation. Clinical remission in rheumatoid arthritis is defined as the absence of signs and symptoms of significant inflammation, this is achieved with prompt diagnosis and response to treatment modifications with close monitoring and control. However, the discrepancy between clinical remission and evidence of continued structural deterioration has led to the postulation of the existence of persistent silent inflammation, also called subclinical inflammation. Therefore, ultrasonography can be used to evaluate subclinical signs of inflammatory activity, as it is more sensitive than clinical evaluation; allowing the disease to be monitored by the characteristics that it contributes both, by the gray scale and by the Doppler Flow. Objective: To determine the value of the 6 joint ultrasound scale in the prediction of clinical remission in patients with rheumatoid arthritis at the Trujillo Regional Teaching Hospital. Material and Methods: An applied, analytical, transversal and prospective study will be developed. The population will be made up of patients with a recent diagnosis of rheumatoid arthritis in the Rheumatology Service of the Trujillo Regional Teaching Hospital in the period from February to April 2024. Descriptive statistics will be presented in single and double entry boxes. Analytical statistics will be obtained with the ROC curve.
Abstract Rheumatoid arthitis is a chronic inflammatory disease, characterized by symmetrical involvement of small and médium sized joints. Pathological lesions are characterized by persistent sinovitis accompanied by synovial hyperplasia with invasion into adjacent tissues and pannus formation. Clinical remission in rheumatoid arthritis is defined as the absence of signs and symptoms of significant inflammation, this is achieved with prompt diagnosis and response to treatment modifications with close monitoring and control. However, the discrepancy between clinical remission and evidence of continued structural deterioration has led to the postulation of the existence of persistent silent inflammation, also called subclinical inflammation. Therefore, ultrasonography can be used to evaluate subclinical signs of inflammatory activity, as it is more sensitive than clinical evaluation; allowing the disease to be monitored by the characteristics that it contributes both, by the gray scale and by the Doppler Flow. Objective: To determine the value of the 6 joint ultrasound scale in the prediction of clinical remission in patients with rheumatoid arthritis at the Trujillo Regional Teaching Hospital. Material and Methods: An applied, analytical, transversal and prospective study will be developed. The population will be made up of patients with a recent diagnosis of rheumatoid arthritis in the Rheumatology Service of the Trujillo Regional Teaching Hospital in the period from February to April 2024. Descriptive statistics will be presented in single and double entry boxes. Analytical statistics will be obtained with the ROC curve.
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Keywords
Artritis Reumatoide, Remisión Clínica, Escala Ultrasonográfica