Efectividad del ácido ascórbico endovenoso en la evolución clínica de pacientes con sepsis y shock séptico
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Date
2024-08-28
Authors
García Llanos, Ricardo Martín
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Publisher
Universidad Nacional de Trujillo
Abstract
La sepsis y el shock séptico son problemas de salud importantes para millones de personas en todo el mundo, aún con una elevada mortalidad pese al esfuerzo de las diferentes sociedades cientificas de brindar guias de tratamiento.
Objetivos:Este proyecto de investigación tiene como objetivo evaluar la efectividad del ácido ascórbico endovenoso en la evolución clínica de pacientes con sepsis y shock séptico realizado en Hospital Regional Docente de Trujillo (Perú). Tiene los siguientes objetivos específicos: 1)Comparar la modificación de la escala SOFA (delta de SOFA) entre pacientes con diagnóstico de sepsis y shock séptico a quienes se les administra Ácido Ascórbico via intravenosa, y el grupo control; 2)Comparar la mortalidad en pacientes con diagnóstico de sepsis y shock séptico a quienes se les administra Acido Ascórbico vía intravenosa, y el grupo control; 3)Comparar el requerimiento de vasopresores (dosis y dias de administracion) en pacientes que reciben Acido Ascorbico via endovenosa, y el grupo control; yComparar la duración de la estancia hospitalaria de pacientes que reciben Acido Ascorbico vía endovenosa, y el grupo control.
Material y métodos: Es un estudio tipo cohorte retrospectiva, cuya población de sstudio son los pacientes con diagnóstico de Sepsis o Shock Septico del Servicio de Emergencia, Hospitalizacion y Unidad de Cuidados Intensivos del Hospital Regional Docente de Trujillo durante el periodo del 9 de septiembre del 2016 al 9 de septiembre del 2023.
Palabras clave: sepsis, shock séptico, ácido ascórbico endovenoso
Abstract Sepsis and septic shock are important health problems for millions of people around the world, even with a high mortality rate despite the efforts of different scientific societies to provide treatment guidelines. Objectives: This research project aims to evaluate the effectiveness of intravenous ascorbic acid in the clinical evolution of patients with sepsis and septic shock carried out at the Regional Teaching Hospital of Trujillo (Peru). It has the following specific objectives: 1) Compare the modification of the SOFA scale (SOFA delta) between patients with a diagnosis of sepsis and septic shock who are administered intravenous Ascorbic Acid, and the control group; 2) Compare mortality in patients with a diagnosis of sepsis and septic shock who are administered intravenous Ascorbic Acid, and the control group; 3) Compare the requirement of vasopressors (dose and days of administration) in patients receiving intravenous Ascorbic Acid, and the control group; yCompare the length of hospital stay of patients receiving intravenous Ascorbic Acid and the control group. Material and methods: It is a retrospective cohort study, whose study population is patients with a diagnosis of Sepsis or Septic Shock from the Emergency Service, Hospitalization and Intensive Care Unit of the Regional Teaching Hospital of Trujillo during the period from September 9, 2016 to September 9, 2023.
Abstract Sepsis and septic shock are important health problems for millions of people around the world, even with a high mortality rate despite the efforts of different scientific societies to provide treatment guidelines. Objectives: This research project aims to evaluate the effectiveness of intravenous ascorbic acid in the clinical evolution of patients with sepsis and septic shock carried out at the Regional Teaching Hospital of Trujillo (Peru). It has the following specific objectives: 1) Compare the modification of the SOFA scale (SOFA delta) between patients with a diagnosis of sepsis and septic shock who are administered intravenous Ascorbic Acid, and the control group; 2) Compare mortality in patients with a diagnosis of sepsis and septic shock who are administered intravenous Ascorbic Acid, and the control group; 3) Compare the requirement of vasopressors (dose and days of administration) in patients receiving intravenous Ascorbic Acid, and the control group; yCompare the length of hospital stay of patients receiving intravenous Ascorbic Acid and the control group. Material and methods: It is a retrospective cohort study, whose study population is patients with a diagnosis of Sepsis or Septic Shock from the Emergency Service, Hospitalization and Intensive Care Unit of the Regional Teaching Hospital of Trujillo during the period from September 9, 2016 to September 9, 2023.
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Keywords
Sepsis, Shock Séptico, Acido Ascórbico Endovenoso