Desarrollo de comprimidos masticables a base de extracto seco de Lepidium meyenii Walp
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Date
2021
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Universidad Nacional de Trujillo
Abstract
El presente trabajo, tuvo como objetivo el desarrollo de comprimidos masticables a base del extracto seco de las raíces de Lepidium meyenii Walp “maca”. El extracto seco fue obtenido a partir del proceso de molienda y tamizado de la materia prima, se obtuvo por el método de decocción y a través de una serie de mecanismos de secado primario y secundario, el que fue colocado en sobres impermeables de polietileno; para la caracterización del extracto seco, se realizaron las pruebas de morfología, determinación de densidad y flujo, distribución granulométrica, porcentaje de humedad, calorimetría diferencial de barrido (DSG) y termogravimetría (TG). Después se elaboró los comprimidos masticables, y se realizó la caracterización mediante las pruebas: peso medio, espesor y diámetro, friabilidad, dureza y tiempo desintegración. Los resultados obtenidos del extracto seco para su morfología fueron discoidal, uniforme y rígida; en la determinación de su densidad y flujo, el índice de Carr fue 42.8 % y la proporción de Hausner 1.75, y el flujo del polvo demasiado pobre, la distribución granulométrica obtuvo partículas inferiores a 0,71 mm, el porcentaje de humedad de 7,55%, y su la obtención de termogramas de DSC y TG, donde se seleccionó los excipientes compatibles con la materia prima. Para su caracterización fisicoquímica de los comprimidos masticables, se evaluó la prueba de peso medio, y se obtuvo 499,667 mg, además de espesor y diámetro de los comprimidos que fueron 12,12 mm y 4,033 mm respectivamente, prueba de friabilidad donde se observó que tiene poca friabilidad, y por último se evaluó la dureza y el tiempo de desintegración, donde se obtuvo 4,4 Kg-f y 40,5 segundos respectivamente.
ABSTRACT The objective of this work was to develop chewable tablets based on the dry extract of the roots of Lepidium meyenii Walp "maca". The dry extract was obtained from the raw material grinding and sieving process, it was obtained by the decoction method and through a series of primary and secondary drying mechanisms, which was placed in waterproof polyethylene envelopes; For the characterization of the dry extract, the tests of morphology, determination of density and flow, granulometric distribution, percentage of humidity, differential scanning calorimetry (DSG) and thermogravimetry (TG) were carried out. Then the chewable tablets were made, and the characterization was carried out by means of the tests: average weight, thickness and diameter, friability, hardness and disintegration time. The results obtained from the dry extract for its morphology were discoidal, uniform and rigid; In determining its density and flux, the Carr index was 42.8% and the Hausner proportion 1.75, and the powder flow was too poor, the granulometric distribution obtained particles less than 0.71 mm, the humidity percentage was 7, 55%, and its obtaining DSC and TG thermograms, where excipients compatible with the raw material were selected. For its physical chemistry characterization of the chewable tablets, the mean weight test was evaluated, and 499.667 mg was obtained, in addition to the thickness and diameter of the tablets, which were 12.12 mm and 4.033 mm respectively, a friability test where it was observed that it has little friability, and finally the hardness and the disintegration time were evaluated, where 4.4 Kg-f and 40.5 seconds were obtained respectively.
ABSTRACT The objective of this work was to develop chewable tablets based on the dry extract of the roots of Lepidium meyenii Walp "maca". The dry extract was obtained from the raw material grinding and sieving process, it was obtained by the decoction method and through a series of primary and secondary drying mechanisms, which was placed in waterproof polyethylene envelopes; For the characterization of the dry extract, the tests of morphology, determination of density and flow, granulometric distribution, percentage of humidity, differential scanning calorimetry (DSG) and thermogravimetry (TG) were carried out. Then the chewable tablets were made, and the characterization was carried out by means of the tests: average weight, thickness and diameter, friability, hardness and disintegration time. The results obtained from the dry extract for its morphology were discoidal, uniform and rigid; In determining its density and flux, the Carr index was 42.8% and the Hausner proportion 1.75, and the powder flow was too poor, the granulometric distribution obtained particles less than 0.71 mm, the humidity percentage was 7, 55%, and its obtaining DSC and TG thermograms, where excipients compatible with the raw material were selected. For its physical chemistry characterization of the chewable tablets, the mean weight test was evaluated, and 499.667 mg was obtained, in addition to the thickness and diameter of the tablets, which were 12.12 mm and 4.033 mm respectively, a friability test where it was observed that it has little friability, and finally the hardness and the disintegration time were evaluated, where 4.4 Kg-f and 40.5 seconds were obtained respectively.
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Keywords
Extracto seco, DSC, TG, formulación, Lepidium meyenii Walp, comprimidos masticables