Validación del método analítico por espectrofotometría de absorción atómica para la cuantificación de hierro III en tabletas masticables
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Date
2020
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Universidad Nacional de Trujillo
Abstract
El presente estudio tuvo como objetivo validar el método analítico por espectrofotometría de absorción atómica para la cuantificación de hierro III en tabletas masticables, mediante la evaluación de la especificidad, linealidad, robustez, exactitud y precisión. El ensayo fue específico para el estándar y la muestra, asimismo, al someterlo a la degradación forzada, su porcentaje de degradación es inferior al límite de conformidad. En el ensayo de linealidad se encontró que, para el estándar, el coeficiente de correlación fue 0,9997 y para el método, 0,9997; y, respecto al coeficiente de determinación se encontraron valores 0,9995 y 0,9993 respectivamente, quedando demostrado el parámetro de linealidad. Del mismo modo, el método demostró exactitud, no existiendo diferencia significativa entre la recuperación promedio (100,27%). En el ensayo de precisión, se evaluó la precisión del sistema y método, y se encontró que el coeficiente de variación fue de 0,246% y 0,371% respectivamente, para la precisión intermedia se obtuvo un valor de 0,161%. Se concluye que el método analítico es específico, lineal, exacto y preciso, aplicable para la cuantificación de hierro III en tabletas masticables.
ABSTRACT The present study aimed to validate the analytical method by atomic absorption spectrophotometry for the quantification of iron III in chewable tablets, by evaluating the specificity, linearity, robustness, accuracy and precision. The test was specific for the standard and the sample, likewise when subjected to forced degradation, its degradation percentage is lower than the compliance limit. In the linearity test it was found that, for the standard; the correlation coefficient was 0,9997 and for the method it was 0,9997 and the determination coefficient was 0,9995 and 0,9993 respectively, the linearity parameter being demonstrated. Similarly, the method demonstrated accuracy, with no significant difference between the average recovery (100,27%). In the precision test, the precision of the system and method was evaluated; and it was found that the coefficient of variation was 0,246% and 0,371% respectively and 0,161% of intermediate precision. It is concluded that the analytical method is specific, linear, exact and precise, applicable for the quantification of iron III in chewable tablets.
ABSTRACT The present study aimed to validate the analytical method by atomic absorption spectrophotometry for the quantification of iron III in chewable tablets, by evaluating the specificity, linearity, robustness, accuracy and precision. The test was specific for the standard and the sample, likewise when subjected to forced degradation, its degradation percentage is lower than the compliance limit. In the linearity test it was found that, for the standard; the correlation coefficient was 0,9997 and for the method it was 0,9997 and the determination coefficient was 0,9995 and 0,9993 respectively, the linearity parameter being demonstrated. Similarly, the method demonstrated accuracy, with no significant difference between the average recovery (100,27%). In the precision test, the precision of the system and method was evaluated; and it was found that the coefficient of variation was 0,246% and 0,371% respectively and 0,161% of intermediate precision. It is concluded that the analytical method is specific, linear, exact and precise, applicable for the quantification of iron III in chewable tablets.
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Keywords
Espectrofotometría