Índice neutrófilo-linfocito (INL) como factor predictor de mortalidad en pacientes COVID-19 admitidos en UCI
No Thumbnail Available
Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Nacional de Trujillo
Abstract
Determinar que el Índice Neutrófilo-Linfocito (INL) es un factor predictor de mortalidad en pacientes con COVID-19 admitidos a la Unidad de Cuidados Intensivos (UCI) del Hospital Regional Docente de Trujillo (HRDT) durante los años 2020 y 2021. Métodos: Estudio observacional analítico de tipo casos y controles en pacientes con COVID-19 admitidos a UCI del HRDT durante los años 2020 y 2021. Se incluyeron 170 pacientes divididos en dos grupos. Se utilizó un análisis de regresión logística para evaluar la asociación entre las variables. Resultados: El punto de corte óptimo fue de 13 y el área bajo la curva fue de 0,803 (IC 95%; 0,74-0,87; p<0,001), con valores de sensibilidad y especificidad de 71,26% y 72,94%, respectivamente. La mortalidad por COVID-19 fue significativamente mayor para aquellos que tuvieron un INL mayor o igual a 13 en comparación de quienes lo tenían inferior a 13 (72,9% vs. 28,7%; p<0,001). Luego, tras ajustar por confusores, el INL≥13 se asoció a mortalidad en pacientes con COVID-19 admitidos a UCI. Conclusión: En la muestra de estudio, el INL≥13 es un factor predictor de mortalidad en pacientes con COVID-19 admitidos a UCI.
To determine that the neutrophil-lymphocyte index (NLI) is a predictor of mortality in patients with COVID-19 admitted to the Intensive Care Unit (ICU) of the Hospital Regional Docente de Trujillo (HRDT) during the years 2020 and 2021. Methods: Analytical observational case-control study in patients with COVID-19 admitted to the ICU of the HRDT during the years 2020 and 2021. 170 patients were included, divided into two groups. Logistic regression analysis was used to assess the association between NLI and mortality. Results: The optimal cutoff point was 13 and the area under the curve was 0.803 (95% CI; 0.74-0.87; p<0.001), with sensitivity and specificity values of 71.26% and 72.94%, respectively. Mortality by COVID-19 was significantly higher for those with an NLI greater than or equal to 13 compared to those with an NLI less than 13 (72.9% vs. 28.7%; p<0.001). Then, after adjusting for confounders, NLI of 13 or more points was associated with mortality in patients with COVID-19 admitted to ICU. Conclusion: In the study sample, NLI with values of 13 or more points is a predictor of mortality in patients with COVID-19 admitted to ICU.
To determine that the neutrophil-lymphocyte index (NLI) is a predictor of mortality in patients with COVID-19 admitted to the Intensive Care Unit (ICU) of the Hospital Regional Docente de Trujillo (HRDT) during the years 2020 and 2021. Methods: Analytical observational case-control study in patients with COVID-19 admitted to the ICU of the HRDT during the years 2020 and 2021. 170 patients were included, divided into two groups. Logistic regression analysis was used to assess the association between NLI and mortality. Results: The optimal cutoff point was 13 and the area under the curve was 0.803 (95% CI; 0.74-0.87; p<0.001), with sensitivity and specificity values of 71.26% and 72.94%, respectively. Mortality by COVID-19 was significantly higher for those with an NLI greater than or equal to 13 compared to those with an NLI less than 13 (72.9% vs. 28.7%; p<0.001). Then, after adjusting for confounders, NLI of 13 or more points was associated with mortality in patients with COVID-19 admitted to ICU. Conclusion: In the study sample, NLI with values of 13 or more points is a predictor of mortality in patients with COVID-19 admitted to ICU.
Description
Keywords
Índice Neutrófilo-Linfocito, Mortalidad, COVID-19