Hiperglucemia como factor predictor de mal estado funcional en pacientes con accidente cerebrovascular isquémico
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Date
2024-02-12
Authors
Cerna Hilario, María José Cristina
Pérez Mantilla, Sandra Daniela
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Nacional de Trujillo
Abstract
Determinar si la hiperglucemia en pacientes con ACV isquémico agudo es un factor predictor de mal estado funcional a los 6 meses.
Materiales y método: Se realizó un estudio observacional, analítico, de cohorte, prospectivo, que incluyó 153 pacientes con ACV isquémico agudo del Hospital Belén de Trujillo en el periodo de octubre 2021 a junio 2023. El mal estado funcional a los 6 meses después del ACV se midió mediante la Escala de Rankin modificada (ERm) y se clasificó como bueno (ERm: 0–2) o malo (ERm: 3–6). Para el análisis de los datos se utilizó un modelo de análisis multivariable de regresión logística, ajustado por variables intervinientes.
Resultados: Se encontró una asociación significativa entre mal estado funcional e hiperglucemia (OR, 27.12; IC 95% 9.74 - 75.51; p=0.0001), sexo femenino (OR 2.26; IC 95% 1.13 - 4.51; p=0.0200), hipercolesterolemia (OR 2.66; IC 95% 1.02 - 6.95; p=0.0407) y Diabetes Mellitus (OR 5.03; IC 95% 1.96 - 12.8; p=0.0003). En el análisis de regresión logística, la hiperglucemia (OR ajustado, 24.176; IC 95% 8.25 - 70.84; p=0.0001), hipercolesterolemia (OR ajustado, 4.279; IC 95% 1.33 - 13.76; p=0.0147) y Diabetes Mellitus (OR ajustado, 3.801; IC 95% 1.20 - 12.00; p=0.0228) fueron predictores independientes de mal estado funcional, mientras que el sexo femenino (OR ajustado, 1.277; IC 95% 0.51 - 3.19; p=0.6005) no mostró asociación significativa.
Conclusiones: La hiperglucemia es un factor predictor independiente estadísticamente significativo de mal estado funcional a los 6 meses en pacientes con diagnóstico de ACV isquémico.
Abstract To determine whether hyperglycemia in patients with acute ischemic stroke (AIS) is a predictor of poor functional status at 6 months. Materials and Methods: An observational, analytical, prospective, cohort study was conducted, including 153 acute AIS patients from Belén Hospital in Trujillo between October 2021 and June 2023. Poor functional status at 6 months post-stroke was measured using the modified Rankin Scale (mRS) and classified as good (mRS: 0–2) or poor (mRS: 3–6). Multivariable logistic regression analysis adjusted for confounding variables was used for data analysis. Results: A significant association was found between poor functional status and hyperglycemia (OR, 27.12; 95% CI 9.74 - 75.51; p=0.0001), female sex (OR 2.26; 95% CI 1.13 - 4.51; p=0.0200), hypercholesterolemia (OR 2.66; 95% CI 1.02 - 6.95; p=0.0407), and Diabetes Mellitus (OR 5.03; 95% CI 1.96 - 12.8; p=0.0003). In the logistic regression analysis, hyperglycemia (adjusted OR, 24.176; 95% CI 8.25 - 70.84; p=0.0001), hypercholesterolemia (adjusted OR, 4.279; 95% CI 1.33 - 13.76; p=0.0147), and Diabetes Mellitus (adjusted OR, 3.801; 95% CI 1.20 - 12.00; p=0.0228) were independent predictors of poor functional status, while female sex (adjusted OR, 1.277; 95% CI 0.51 - 3.19; p=0.6005) showed no significant association. Conclusions: Hyperglycemia is a statistically significant independent predictor of poor functional status at 6 months in patients diagnosed with acute ischemic stroke.
Abstract To determine whether hyperglycemia in patients with acute ischemic stroke (AIS) is a predictor of poor functional status at 6 months. Materials and Methods: An observational, analytical, prospective, cohort study was conducted, including 153 acute AIS patients from Belén Hospital in Trujillo between October 2021 and June 2023. Poor functional status at 6 months post-stroke was measured using the modified Rankin Scale (mRS) and classified as good (mRS: 0–2) or poor (mRS: 3–6). Multivariable logistic regression analysis adjusted for confounding variables was used for data analysis. Results: A significant association was found between poor functional status and hyperglycemia (OR, 27.12; 95% CI 9.74 - 75.51; p=0.0001), female sex (OR 2.26; 95% CI 1.13 - 4.51; p=0.0200), hypercholesterolemia (OR 2.66; 95% CI 1.02 - 6.95; p=0.0407), and Diabetes Mellitus (OR 5.03; 95% CI 1.96 - 12.8; p=0.0003). In the logistic regression analysis, hyperglycemia (adjusted OR, 24.176; 95% CI 8.25 - 70.84; p=0.0001), hypercholesterolemia (adjusted OR, 4.279; 95% CI 1.33 - 13.76; p=0.0147), and Diabetes Mellitus (adjusted OR, 3.801; 95% CI 1.20 - 12.00; p=0.0228) were independent predictors of poor functional status, while female sex (adjusted OR, 1.277; 95% CI 0.51 - 3.19; p=0.6005) showed no significant association. Conclusions: Hyperglycemia is a statistically significant independent predictor of poor functional status at 6 months in patients diagnosed with acute ischemic stroke.
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Keywords
Glucemia en ayunas, Hiperglucemia, ACV isquémico, ICTUS, Estado funcional, Diabetes