Efectividad del recuento leucocitario e índice neutrófilo/linfocito en el pronóstico de pancreatitis aguda
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Date
2023-03-27
Authors
Espinola Rivera, Cynthia Katherine
Cortijo Marquina, Claudia Lucia
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Nacional de Trujillo
Abstract
Identificar la efectividad del recuento leucocitario e índice neutrófilo linfocito (INL) en el pronóstico de pancreatitis aguda (PA). MATERIAL Y MÉTODO: Estudio analítico de pruebas diagnósticas, se seleccionaron 269 historias clínicas de pacientes con PA; recuento leucocitario > 19 000, INL > 7.13, presencia de mortalidad, falla orgánica (FO) y complicaciones se colocaron en tablas 2x2, se halló sensibilidad (S), especificidad (E), valor predictivo positivo (VPP) y valor predictivo negativo (VPN), razón de verosimilitud positiva (LR+) y razón de verosimilitud negativa (LR-), en caso resultados no fueran significativos se usaría curvas ROC y AUC. RESULTADOS: Un recuento leucocitario > 19 000 e INL >
7.13 no pronosticaron mortalidad (S:27.27%, E:89.58%, VPP:10%, VPN:96.67% vs S:72.73%, E:47.1%, VPP:5.52%, VPN:97.6%), complicaciones (S:14.94%, E:90.71%, VPP:43.33%, VPN:69.17% vs S:57.47%, E:48.63%, VPP:34.72%, VPN:70.63%) ni FO (S:21.05%, E:89.64%, VPP:13.33%, VPN:93.75% vs S:57.89%, E: 46.61%, VPP:7.59%, VPN:93.6%). Se utilizó curva ROC y AUC, no encontrándose un punto de corte significativo. CONCLUSIÓN: Recuento leucocitario e INL no son efectivos en el pronóstico de PA, aunque, se sugiere su utilidad para identificar menor riesgo de mortalidad, complicaciones y FO.
Description
To identify the effectiveness of the leukocyte count and neutrophil- lymphocyte index (INL) in the prognosis of acute pancreatitis (AP). MATERIAL AND METHOD: Analytical study of diagnostic tests, 269 medical records of patients with AP were selected; leukocyte count > 19,000, INL > 7.13, presence of mortality, organ failure (FO) and complications were placed in 2x2 tables, sensitivity (S), specificity (E), positive predictive value (PPV) and negative predictive value ( NPV), positive likelihood ratio (LR+) and negative likelihood ratio (LR-), if results were not significant, ROC and AUC curves would be used. RESULTS: A leukocyte count > 19,000 and INL > 7.13 did not predict mortality (S:27.27%, E:89.58%, PPV:10%, NPV:96.67% vs S:72.73%, E:47.1%, PPV:5.52% , NPV:97.6%), complications (S:14.94%, E:90.71%, PPV:43.33%, NPV:69.17% vs S:57.47%, E:48.63%, PPV:34.72%, NPV:70.63%) or OF (S:21.05%, E:89.64%, PPV:13.33%, NPV:93.75% vs S:57.89%, E: 46.61%, PPV:7.59%, NPV:93.6%). ROC and AUC
curve were used, not finding a significant cut-off point. CONCLUSION: Leukocyte count and INL are not effective in the prognosis of AP, although their usefulness is suggested to identify a lower risk of mortality, complications and OF.
Keywords
Pancreatitis aguda, Recuento leucocitario, Indice neutrófilo-linfocito, Falla orgánica, Mortalidad, Complicaciones